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In line with this work, MET is enriched, during forebrain formation, in developing axon tracts and in the neuropil, mostly in pre- and post-synaptic compartments, mirroring an active transport to the synapse (Judson et al., 2009

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Together, these findings support a model in which ghrelin‐responsive Kiss1 neurons recruit NPY and GHRH populations to form a metabolic–reproductive relay (Kiss1 → NPY → GHRH) that coordinates GH secretion with nutritional and hormonal state